A Synthetic Approach towards Novel Series of 3-(3-(1-piperazinyl)propyl -1h-indole Derivatives as Monoaminergic Multi-target Agents. Docking Studies and Pharmacological Evaluation at Sert, D2, and Mao-a Receptors

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------Major depression is a common, heterogeneous and often incapacitating disorder triggered by a complex pattern of genetic, epigenetic, developmental and environmental factors. Antidepressant drug discovery has been a complex task, due to incomplete understanding of neurobiological basis of depression, thus no single molecular target can be rationalized as an ultimate therapeutic strategy. Several reports have recognized the pivotal status of the serotonergic system and the antidepressant drugs, as a central dogma of depression. Although commonly used antidepressants, such as the selective serotonin reuptake inhibitors (SSRIs) are often effective, full efficacy is only apparent after several weeks, and many patients only respond partially. For these reasons, efforts in developing newer, faster and safer antidepressant agents are still ongoing.